Glucosamine which one

Studies have also differed on which of these supplements offers the greatest benefit for OA. Some find chondroitin to be superior, others favor glucosamine, while still others prefer a combination of the two. The ideal form of glucosamine has also caused dissent in the research community. Some studies show an advantage to glucosamine sulfate; others to glucosamine hydrochloride. One study that compared the two glucosamine forms head to head found no real difference between them.

Mayo Clinic researchers agree, saying that evidence supports trying glucosamine sulfate — not hydrochloride — with or without chondroitin sulfate for knee OA.

Glucosamine and chondroitin are considered safe, with no serious side effects reported in studies. However, these supplements can interact with blood thinners like warfarin Coumadin. They might also affect blood sugar levels, and one small study found they raise eye pressure, which could increase the risk for glaucoma.

If you have diabetes or glaucoma, you may need to avoid these supplements, or have your doctor monitor your blood sugar levels and eye pressure more closely while you take them. That means that there isn't strong evidence that benefits outweigh risk, but the supplement could be helpful for people with OA. Also, be patient.

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Honor a loved one with a meaningful donation to the Arthritis Foundation. We'll send a handwritten card to the honoree or their family notifying them of your thoughtful gift. Other reported side effects include. A small study found that taking glucosamine may increase the risk of glaucoma, a condition that can threaten vision if not treated. Chondroitin may act as a blood thinner, so it comes with a warning about potential bleeding.

Many doctors warn patients that the FDA does not regulate supplements such as glucosamine and chondroitin, so they may not contain the amounts stated on the label or there could be contaminants in them. But if a patient is interested in taking these supplements, I rarely object. And if, after a period of time, they have noticed no improvement, I will suggest they discontinue them. As long as they have the information they need and the treatment seems safe, whether to take an over-the-counter supplement for joint symptoms is a decision I leave to my patients.

There are different types and doses available and they are taken for a number of different conditions. There may be certain situations in which they are particularly helpful. As a service to our readers, Harvard Health Publishing provides access to our library of archived content.

Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Does anyone have any information concerning the effect, if any, of glucosamine on blood sugar levels?

I have read a few research papers but none seem to have provided conclusive evidence eith for or against. METHODS: We randomly assigned patients with symptomatic knee osteoarthritis to receive mg of glucosamine daily, mg of chondroitin sulfate daily, both glucosamine and chondroitin sulfate, mg of celecoxib daily, or placebo for 24 weeks.

Up to mg of acetaminophen daily was allowed as rescue analgesia. The primary outcome measure was a 20 percent decrease in knee pain from baseline to week Overall, glucosamine and chondroitin sulfate were not significantly better than placebo in reducing knee pain by 20 percent. As compared with the rate of response to placebo The rate of response in the celecoxib control group was For patients with moderate-to-severe pain at baseline, the rate of response was significantly higher with combined therapy than with placebo Adverse events were mild, infrequent, and evenly distributed among the groups.

Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain. Copyright Massachusetts Medical Society. When I take the pills after eating some food, I have NO problems. Occasionally, however, I forget the food — and then I have stomach burn! Hi Aly I have been taking supplements for the last 9 years for joints and energy.

I was told and directed to take ith food or after. Hope this helps. I have taken this for years and it has helped me so much! The problem is it raises my blood pressure, even with my blood pressure medicine, so I had to stop taking it. My arthritis pain was so bad I started it again, and up went my blood pressure.

So I stopped again and I take MSM for pain and optimized quercetin and bromelain , taurine and a few other supplements that help arthritis and I think I have found the answer.

My blood pressure went down and no pain! I cannot afford to go to a doc. The proof is in the pudding as the old saying goes. My sis has problems with iodine so she cannot take it.

I am still trying to find a safe one for her. Thank you!! The key is in the efficacy of the brand. The ingredients used, I believe, will affect the way it is absorbed. This brand has definitely worked for me — both in pain management and slowing the deterioration of cartilage. I started after my first hip replacement having been told my other hip would be following soon.

After 15 years I finally had my other hip replaced. No study will change my mind. Have you discovered the fountain of youth? I explained about the doggy glucosamine pills and the neighbour was so very impressed with the change in Mopsy that she began taking glucosamine herself for joint stiffness.

So one double-blind observation, in favour of glucosamine improving agility in an old bichon. And my neighbour reports that her knees feel much better, but she does know what she is swallowing ….

In uncontrolled studies of knee arthroscopy for osteoarthritis, about half the patients report relief from pain…. Measure ad performance. Select basic ads. Create a personalised ads profile. Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. Glucosamine is a dietary supplement that is often combined with another supplement, chondroitin , to treat osteoarthritis.

Glucosamine is made from the shells of shellfish and chondroitin is derived from cow trachea. Evidence published in the New England Journal of Medicine in suggested that glucosamine alone or combined with chondroitin can help relieve osteoarthritis pain in a subgroup of people with moderate to severe knee osteoarthritis. It should be noted that based on further research, the American Academy of Orthopedic Surgeons currently advises against the use of glucosamine sulfate, chondroitin sulfate, and glucosamine hydrochloride in treating symptomatic knee osteoarthritis.

Supplements advertised for improved joint health can be confusing and even downright misleading. And that can be a problem. If you take too much, you may be increasing the risk of side effects. Results of a study from Tufts-New England Medical Center conclude that typical doses listed on over-the-counter supplements are probably not strong enough to help relieve arthritic joint pain and stiffness.

To this end, the recommended dosages are based more on what amount of drug causes little to no harm yet is believed to offer therapeutic benefits.

The initial dose is typically 1, milligrams mg of glucosamine and 1, mg of chondroitin daily for one to two months. If a response is obtained, the dose can be reduced to 1, mg of glucosamine and mg of chondroitin per day. According to the Tufts study, it is still unclear as to whether higher doses are more effective and whether that level of dosing may cause potential harm.

More to Consider. If your joints hurt, see your health care provider. Some diseases that cause joint pain—such as rheumatoid arthritis—may need immediate treatment. If you take warfarin or have blood sugar problems, make sure you talk to your doctor about potential side effects if you are considering or taking glucosamine or chondroitin supplements. Help your health care providers give you better coordinated and safe care by telling them about all the health approaches you use.

Give them a full picture of what you do to manage your health. Key References. Archives of Biochemistry and Biophysics. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints—a randomized, controlled, short-term study.

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine. The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature. Osteoarthritis and Cartilage. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center.

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. American College of Rheumatology recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee.

Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.

Archives of Internal Medicine. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Annals of Internal Medicine. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT.

Annals of the Rheumatic Diseases. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. Journal of Rheumatology.